There were 34 goals in 9 UEFA Champions League matches on Wednesday 21 October.
- Como 4–1 Manchester United. Como: Nico Paz (2′, 57′), Anastasios Douvikas (49′) and Jacobo Ramón (76′). Manchester United: Joshua Zirkzee (90+1′).
- Lille 2–4 Galatasaray.
- Internazionale 1–0 Shakhtar Donetsk. Internazionale: Carlos Augusto (77′).
- Real Madrid 4–1 RB Leipzig.
- Real Betis 1–0 Feyenoord Rotterdam.
- Sporting CP 2–3 LASK Linz.
- Aston Villa 3–1 Viking FK.
- Bayern Munich 2–2 Arsenal.
- Club Brugge 3–0 Lens. Club Brugge: Hans Vanaken (45+3′), Joaquin Seys (50′) and Carlos Forbs (72′).
The biggest wins, each by 3 goals, were Como’s 4–1 against Manchester United, Real Madrid’s 4–1 against RB Leipzig and Club Brugge’s 3–0 against Lens. The most goals came in Lille 2–4 Galatasaray, 6 in all.